Abstract

ROJAS MARTINEZ, Roberto Luis; MARTINEZ MARRERO, Concepción; PEREZ CABRERA, Adalberto  and  ROJAS DEL CALVO, Adriana María. Efectos de la hindarina sobre las aurículas aisladas. Rev Cubana Farm [online]. 1997, vol.31, n.3, pp. 192-198. ISSN 1561-2988.

The effects of hindarine and of chlorpromazine on the amplitude and frequency of the spontaneous contractions of rats' isolated atria are presented. Hindarine produced a moderate bradycardia and a discreet increase of the contractions in a dosage-dependent way. Chlorpromazine caused a greater depression of the frequency and amplitude of these contractions. The cholinergic or beta-blocker action was discarded in the production of bradycardia brought about by hindarine. It was also eliminated a cadiotonic action of hindarine in the isolated atria of guinea pig depressed by hypocalcic solution or by hipoxia. It is suggested its study as an antiarrhythmic.

Keywords : MEDICINAL PLANTS; ALKALOIDS [isolation and purification]; RATS, WISTAR; GUINEA PIGS; ALKALOIDS [pharmacology]; CHLORPROMAZINE [pharmacology]; HEART ATRIUM [drug effects].