Abstract

BERMUDEZ CAMPS, Isis B; TORRES ALEMAN, María A; LEON FERNANDEZ, Olga Sonia  and  TAMAKI TAMAKI, Pedro. Atenuación del efecto hepatotóxico del tetracloruro de carbono en ratas tratadas con Polypodium polypodiodes. Rev Cubana Farm [online]. 1999, vol.33, n.2, pp. 132-136. ISSN 1561-2988.

The benefits of Polypodium polypodiodes in reducing hepatotoxic effects caused by carbon tetrachloride which gives rise to increased level of lipid peroxides and blood transaminase were tested in rats under lab conditions. Glutamicpiruvic trnnsaminane level was lower tham the normal lavels due to the administration of a 300 mg/kg dosege of the plant extract. The activities of both lipid peroxides and glutamicoxalacetic transaminase were reduced but not in a remarkable way showing that the hepatic damage is still present despite the partial recovery. The results were confirmed using and anatomytological study. Lidewise, acute toxicity resulted from oral administration of plant extrac was determined. It was observed that DL50 level was over 1g/kg, so this preparation may be considered relatively harmless in lab animals.

Keywords : CARBON TETRACHLORIDE [adverse effects]; LIVER DISEASES [chemically induced]; ASPARTATE TRANSAMINASE [analysis]; ALANINE TRANSAMINASE [analysis]; PLANT, MEDICINAL; LIPID PER OXIDATION.

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