Abstract

FERNANDEZ MONAGAS, Sol Amalia  and  BODES RAMIL, Orlando. Determinación de las variables significativas en la obtención de 2 derivados de quitina. Rev Cubana Farm [online]. 2002, vol.36, n.2, pp. 79-82. ISSN 1561-2988.

After applying a fraction factor design 27-4, it was determined that the most significant variables for the introduction of carboxyl groups in the chitin molecule were time of reaction with monochloroacetic acid, the concentration of this acid, the pre-treatment temperature of chitin with sodium hydroxide, and the concentration of sodium hydroxide. The most significant variables in the formation of the amino group were the concentration of monochloroacetic acid, the reaction temperature with monochloroacetic acid, the pre-treatment temperature of chitin and the concentration of sodium hydroxide.

Keywords : DRUG DESIGN; TECHNOLOGY, PHARMACEUTICAL; CHITIN [analogues & derivatives]; SODIUM HYDROXIDE; DRUG COMPOUNDING..

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