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Revista Cubana de Farmacia
On-line version ISSN 1561-2988
Abstract
GARCIA PULPEIRO, Oscar and SUAREZ PEREZ, Yania. Development and validation of a new method for chitin dehomogenization estimation in suppositories. Rev Cubana Farm [online]. 2005, vol.39, n.3, pp. 0-0. ISSN 1561-2988.
For the first time, the development of a simple alternative method to determine chitin dehomogenization in rectal suppositories was addressed in this paper. The suggested method is based on determination of dehomogenization from the ratio of chitin density of the tip and of the base of suppository. For estimation of the sliding density, the clearing factor as well as various mathematical calculations were taken into consideration. The method was validated for quality control, it was satisfactory and applied in 11 formulations. It was proved that the increase in chitin particle size and dose in suppository favors sedimentation to the tip of suppository. In the analyzed interval, the dehomogenization values were considered minimal, so the technological quality of the studied formulations was not affected.
Keywords : Chitin; suppository; dehomogenization.