Abstract

GALAN MARTINEZ, Loipa et al. Synthesis of new hexahydroquinoline derivatives and pharmacological evaluation of their calcium antagonist properties. Rev Cubana Farm [online]. 2006, vol.40, n.3, pp. 0-0. ISSN 1561-2988.

Five hexahydroquinolines were prepared through one-step synthesis from an aromatic aldehyde called ß- alkyl aminocrotonate (enamin)and dimedone in pure ethanol as solvent. The effects of the five hexahydroquinolines on contractility of rabitt´s aorta rings and on contractility of papillar muscles of rat´s right ventricle were characterized in a comparative way to classical nifedipine. All hexahydroquinolines inhibited the contractile activity of both vascular smooth muscle and cardiac muscle, and they showed effects that are characteristic of calcium antagonist compounds, although with less potent action than nifedipine. However, two of the studied hexahydroquinolines presented some mild vasoselectivity.

Keywords : Calcium antagonists; hexahydroquinolines; dihydropyridines; vasoselectivity.