Abstract

TENORIO VERGARA, José Luís; HERNANDEZ,2 CARVAJAL, Jorge Enrique; ADOLFO VALLEJO, Gustavo  and  DAIRO RAMOS, John. Trypanomicidal activity of etanol extract from Xylopia aromatica on Tripasonoma cruzi. Rev Cubana Farm [online]. 2006, vol.40, n.3, pp. 0-0. ISSN 1561-2988.

Chagas´s disease affects the most underprivileged communities in Departamento de Tolima, Colombia; the poorly accessible treatment and the parasite´s resistance to traditional drugs make it necessary to search for alternative therapies at present. This study assessed the trypanomicidal activity of methanol fraction of ethanol extract from Xylkopia aromatica seeds(Annonaceae) that had cytotoxic activity,with presence of Acetogenins being detected. This fraction was tested at different concentrations to Trypanosoma cruzi epimastigotes, and Benzanidazol® was used as reference drug. Methanol fraction showed parasiticidal properties, being more effective than the reference drug at concentrations over 211,6 µg/mL at which 70 % of organisms die.

Keywords : Acetogenins; Chagas; Xylopia aromatica .