Abstract

TORRES AMARO, Leonid; GARCIA PENA, Caridad M.  and  PARDO RUIZ, Zenia. Analytical method by high resolution liquid chromatography for the stability study of loratidine syrup 0.1 %. Rev Cubana Farm [online]. 2007, vol.41, n.1, pp. 0-0. ISSN 1561-2988.

A high resolution liquid chromatography method was validated to study the stability of loratidine syrup 0.1 %. The calibration curve in the range from 13.6 to 3.36 µg/mL was lineal, with a coefficient of correlation equal to 0.99975. The intercept and slope statistical test was not significant. The recovery obtained was 100.2 % in the concentration range studied, and the Cochran and Student (t) tests results were not important. The variation coefficient in the repeatability study was equal to 0.41 % for 10 replications assayed, whereas in the reproducibility Fischer and Student tests were not remarkable. The method proved to be specific, lineal, accurate, and exact.

Keywords : Loratidine; high resolution liquid chromatography; validation..