Abstract

DE LA PAZ MARTIN-VIANA, Nilia et al. Development of formulation for oral suspension Ibuprofen 100 mg/5mL for pediatric use. Rev Cubana Farm [online]. 2009, vol.43, n.2, pp. 0-0. ISSN 1561-2988.

Authors used the test and error method to develop the formulation of Ibuprofen oral suspension (100 mg/5 mL) for pediatric use. Its chemical-physic stability was studied through accelerated method and shelf life. It was bottled in amber glass small bottles by 120 mL, and it was stored at room temperature. A rheology study and assessment of apparent viscosity was made as well as a microbiologic one by test of effectiveness of antimicrobial preservative and the microbial count. Product safe was verified by toxicology study. All results fulfilled quality limits established in scientific literature, USP 30, for this type of pharmaceutical method. We conclude that drug developed is correctly formulated, from the doctoral point of view with a time of useful life of 24 months under study conditions.

Keywords : Stability; Ibuprofen; suspension.

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