Abstract

CRUZ ARENCIBIA, Jorge et al. Chromium (III) phosphate labelled with several radionuclides for use in radiosynoviothersis. Rev Cubana Farm [online]. 2012, vol.46, n.2, pp. 162-172. ISSN 0034-7515.

Introduction: radiosynoviorthesis is used in treating chronic synovitis, a frequent complication of some systemic diseases as rheumatoid arthritis and hemophilia. There are different colloids and radioactive suspensions recommended in the international clinical practice, but the number is reduced and the availability limited. Objective: obtaining and physical-chemical characterization of suspensions of chromium phosphate (III) labeled with several radionuclides as potential radiopharmaceuticals for using in radiosynoviorthesis. Methods: the suspensions were obtained by chemical synthesis. Radionuclides were added at the beginning or after concluding the reaction. The particle size was estimated by means of optic microscopy and membrane filtration. Similarly, the stability of suspension when re-suspended in several media was evaluated by spectrophotometry. The radiochemical purity was determined by paper chromatography. Results: a suspension of chromium (III) phosphate was obtained and characterized. It was found that the obtained product had a predominant particle size range of 0,8 to 5 µm and that when suspended in 2 % gelatin solution in 1mg/ml acetate buffer, it settled in no less than 3 hours. Technologies for the preparation of radiopharmaceuticals of Chromium (III) Phosphate labeled with ³²P and ⁹⁰Y were described. There was demonstrated the feasibility of labeling the obtained suspension with other trivalent radionuclides such as ¹⁷⁷Lu and ⁶⁸Ga. Conclusions: the results allow considering the obtained Chromium (III) Phosphate suspension as a matrix for the preparation of radiopharmaceuticals to be used in radiosinoviorthesis aimed at various joints, depending on the physical and nuclear characteristics of the radionuclides.

Keywords : radiopharmaceuticals; radiosynoviorthesis; Chromium phosphate; synovitis; rheumatoid arthritis; hemophilia.

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