Abstract

GARCIA PENA, Caridad Margarita et al. Simultaneous determination of Albendazol and Triclabendazol in Triclazol 22 suspension for veterinary purposes. Rev Cubana Farm [online]. 2013, vol.47, n.2, pp. 167-177. ISSN 0034-7515.

Introduction: triclazol 22 suspension containing triclabendazol and albendazol is used as parasiticide for veterinary purposes. Objective: to validate the analytical method for simultaneous determination of triclabendazol and albendazol in triclazol 22 suspension for quality control. Methods: for quantitation of the active principle in the final product, the separation was performed through a liquid chromatographic column Lichrosorb RP-18 (5 µm) (250 x 4 mm), with ultraviolet detection range of 298 nm, by using a mobile phase of acetonitrile: ammonium acetate buffer solution of ph 6.6 (70:30); the quantitation was made against a reference sample by means of the external standard method. Results: the results of the evaluated parameters in this validation yielded that they were within the set limits. Conclusions: The validated analytical method was linear, precise, exact and specific in the range of studied concentrations.

Keywords : triclabendazol; albendazol; triclazol; validation.

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