Abstract

ROMAN, Juliana; GARCIA, Cassia Virginia; LOUREIRO MENDEZ, Andreas Sebastian  and  BARCELLOS DA SILVA, Fabiana Ernestina. Development and evaluation of tablets from spray dried extract of yerba mate (Ilex paraguariensis St. Hil A). Rev Cubana Farm [online]. 2013, vol.47, n.3, pp. 379-388. ISSN 0034-7515.

Introduction: yerba mate (Ilex paraguariensis St. Hil A) is a South American plant species of Aquifoliaceae family. The presence of methylxanhtines and clorogenic acids was reported in this species. These compounds have antioxidant activity and could be included in tablets, a pharmaceutical form presently unavailable in the market. Objective: to develop tablets containing yerba mate spray dried extract. Methods: the tablets were produced by direct compression with yerba mate dried extract. The dried extract was evaluated for yield, repose angle, compressibility index, residual moisture and caffeine content. The tablets were evaluated in the following parameters: external appearance, weight, hardness, friability, disintegration and caffeine content. Results: the tablets complied with the general pharmacopoeial specifications. Conclusions: this method is effective to produce tablets containing spray dried extract from yerba mate.

Keywords : Ilex paraguariensis St. Hil. A; caffeine; tablets; direct compression; yerba mate.

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