Abstract

MARTINEZ ALVAREZ, Luis Octavio; ALEJO CISNEROS, Pedro; GARCIA PEREIRA, Reynaldo  and  CAMPOS VALDEZ, Doraily. Validation of the analytical method for sodium dichloroisocyanurate aimed at drinking water disinfection. Rev Cubana Farm [online]. 2014, vol.48, n.2, pp. 191-198. ISSN 0034-7515.

Introduction: Cuba has developed the first effervescent 3.5 mg sodium dichloroisocyanurate tablets as a non-therapeutic active principle. This ingredient releases certain amount of chlorine when dissolved into a litre of water and it can cause adequate disinfection of drinking water ready to be taken after 30 min. Objective: developing and validating an analytical iodometric method applicable to the quality control of effervescent 3.5 mg sodium dichloroisocyanurate tablets. Methods: quantitation of the free active chlorine content in effervescent tablets by using a potentiometric method based on the platinum electrodes and the tittered 0.1 N sodium thiosulphate solution. The developed method was validated as per the category I parameters including the techniques for quantitation of the active principles in the finished forms. Additionally, other tests were conducted to evaluate the influence of the analyst and of the day on the analytical results. Results: the evaluated parameters in the validation of the method were within the set limits. The method was specific, linear, exact and precise in the range of studied concentrations. Conclusions: the results proved that this method can be used in a safe reliable way.

Keywords : free chlorine; effervescent tablets; sodium dichloroisocyanurate.

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