Abstract

PEREZ MENENDEZ, Roberto et al. Omeprazole and short therapy with antihelicobacterpylori tinidazole-azithromycin in patients with duodenal ulcer. Rev cubana med [online]. 2004, vol.43, n.2-3, pp. 0-0. ISSN 1561-302X.

A prospective study of 40 patients with duodenal ulcer infected with Helicobacter pylori (histology and urease test) was conducted. They were treated with 20 daily mg of omeprazole during 28 days. Group A (20 patients) received short therapy with 500 mg of azithromycin twice a day for 3 days and a unique dose of tinidazole 2g. Group B (20 patients) was administered 500 mg of metronidazole 3 times a day and 500 mg of tetracycline 4 times a day, both during 7 days. The infection and healing of the ulcer was investigated a month and a half after concluding the treatment by using the same tests applied for the inclusion of the patient in this study. The negativity of both was taken into account as an eradication criterion. The eradication rate of group A (80 %) was higher than that of group B (70 %). A satisfactory clinical evolution was observed in the groups. A rapid improvement of the symptoms was reported in all patients from group A, and there were no side effects. In group B, 9 patients referred to nausea and metallic taste as the most common side effects. The healing of the injury was 90 % in each group. The eradication failed in 2 patients with ulcer from each group. The association of omeprazole and short therapy with azithromycin and tinidazole offers advantages over the use of omeprazole with metronidazole and tetracycline for presenting a higher eradication rate, convenient posology and no side effects

Keywords : Duodenal ulcer; short therapy; omeprazol; Helicobacter pylori.