Abstract

PINOL JIMENEZ, Felipe; SALVADOR PRATO, Juan C.; PANIAGUA ESTEVEZ, Manuel  and  BORBOLLA, Elvira. Characteristics of the infection due to Helicobacter pylori in patients with gastric adenocarcinoma. Rev cubana med [online]. 2005, vol.44, n.5-6, pp. 0-0. ISSN 1561-302X.

A descriptive prospective study was conducted in adults of both sexes with clinical and endoscopic suspicion of malignant gastric neoplasia aimed at describing the behavior of infection caused by Helicobacter pylori in patients with histological diagnosis of gastric adenocarcinoma. It was found a frequency of gastric adenocarcinoma of 91 %. 60 % were mainly located in the antral region. It was confirmed by urease test that Helicobacter pylori colonizes with low frequency the zones distant from the tumor. The histology of the tumor periphery was analized and it was proved that 70 % of the adenocarcinomas presented Helicobacter pylori in this zone. On comparing this frequecny with that of the peritumoral region (75 %), no statistically significant differences were observed. The presence of Helicobacter pylori was related to the type of gastritis present in the peritumoral mucosa, according to the localization of the tumor. No statistically significant differences were detected between the presence or not of Helicobacter pylori in the different regions where gastritis was studied. In the intestinal histological type it was found a discreet increase of patients with positive Helicobacter pylori (80 %). However, there is no a statistically significant relation between the presence of Helicobacter pylori and and the histological type of tumor. In all the studied biopsy specimens the Helicobacter pylori density was mild. It was concluded that the highest frequency of malignant gastric neoplasia was the adenocarcinoma. There were no significant differences neither in the distribution of Hel icobacter pylori according to the histological type of tumor, nor in the gastritis of the peritumoral mucosa

Keywords : Helicobacter pylori; gastric adenocarcinoma.

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