Abstract

BENITEZ LLANES, Orestes et al. Indicators of evolutive prediction in primary IgA nephropathy. A cooperative study. Rev cubana med [online]. 2006, vol.45, n.2, pp. 0-0. ISSN 1561-302X.

A cooperative, retrospective and descriptive study was conducted to approach the knowledge of the frequency of primary IgA nephropathy, and to identify elements of evolutive prediction in the patients diagnosed with this disease by its clinical manifestations and histological expressions. The following variables wre analyzed: age, sex, color of the skin, tensional figures, persistent proteinuria, histological patterns and the presence or no of tubulointerstitial alterations in the histological renal study, which were related to the variable of renal function response. The point and interval relative risk was calculated, and the homogeneity test was used. It was found that this nephropathy accounted for 7.9 % (72/899) of the total of biopsies performed and for 14.3 % (71/496) of the primary glomerular diseases. Average age was 28.7 ± 11.7 years old, and the white individuals (55/71; 77.5 %) and males (47/71; 66.2 %) were the most frequently affected. Recurrent macroscopic hematuria was the most common clinical presentation (33/71; 46.5 %). In 21.1 % (15/71) of the patients different stages of renal function deterioration were found. It was possible to identify significant statistical associations (p < 0.01) between this variable and arterial hypertension [ RR=6.14; CI 95 % (1.90-19.84) ] and a histological pattern of diffuse crescentic glomerulonephritis. Tubulointerstitial alterations [RR=4.61; IC 95 % (1.42?14.93)] were also found in the histological study by percutaneous kidney biopsy. It was concluded that the presence of arterial hypertension, a histological pattern of diffuse crescentic glomerulonephritis and the finding of tubulointerstitial alterations were elements of poor prognosis in the evolution of this disease.

Keywords : IgANp; arterial hypertension; diffuse CGN; tubulo-interstitial alterations.