Abstract

DORTA GURIDI, Zaily; ARUS SOLER, Enrique Rogelio  and  CALZADILLA BERTOT, Luis. Association between chronic hepatitis C virus infection and non-Hodgkin B cell lymphoma. Rev cubana med [online]. 2014, vol.53, n.4, pp. 468-477. ISSN 0034-7523.

170 million people are estimated to be infected with hepatitis C virus (HCV) worldwide. The persistence of the virus in the body is due to its ability to mutate and alterations in the immune response that occurs. There are theories linking this virus lymphoma genesis. The relative risk of HCV-infected patients suffering from non-Hodgkin lymphoma is 2-4 times higher than in uninfected subjects. This association has geographic variability. Countries where the association is stronger are Italy, Japan, and the United States, and it is lesser in Canada and northern Europe. Lymphoma of the marginal zone in B cells and lymphoplasmacytic are the most well-informed in association with HCV. Indolent non-Hodgkin lymphomas associated with HCV can be treated with antiviral therapy, but the aggressive forms require specific immunochemotherapy. Hepatitis C has been shown to be a significant risk factor for hepatic toxicity in patients needing chemotherapy.

Keywords : chronic hepatitis C virus; non-Hodgkin lymphoma (NHL).

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