Abstract

MENA MIRANDA, Vivian R.; RIVERON CORTEGUERA, Raúl L.  and  PEREZ CRUZ, José A.. Nuevas consideraciones fisiopatológicas sobre el síndrome de respuesta inflamatoria sistémica relacionada con la sepsis. Rev Cubana Pediatr [online]. 1996, vol.68, n.1, pp. 57-70. ISSN 1561-3119.

The septic shock is one of the first causes of morbidity and mortality in intensive care units, and the systemic inflammatory response syndrome (SIRS) is a part of the evolutive stages related to the infection, that were modified by Jaffari for its application in the pediatric age. Septic shock is related with the organism exposition to exogenous agents, and/or endogenous mediators that produce an inadequate histic perfusion with alteration in oxygen consumption, in vascular permeability, and the presentation of hemodynamic disorders that compromise the patient's life. It is considered that the main mediator in septic shock is the tumoral necrosis factor - (TBF- ), although other cytosines also reply in an uncontrolled fashion, the polymorphonuclears, the contact system, the fibrinolytic, the coagulation one, as well as other endogenous substances. Knowing the physiopathology of septic shock renders possible the diagnosis and an early treatment, specially in the risk groups, and the decrease of the mortality by this affection in the intensive care units.

Keywords : SEPSIS SYNDROME [physiopathology]; SEPSIS SYNDROME [etiology]; LIPIDS [metabolism]; BLOOD PROTEINS; NEUTROPHILS.