Abstract

VALDIVIA ALVAREZ, Ileana et al. Efficacy of Vigabatrin in refractory epilepsy in children. Rev Cubana Pediatr [online]. 2007, vol.79, n.3, pp. 0-0. ISSN 1561-3119.

The therapeutical response to Vigabatrin in add-on therapy was evaluated in 28 patients diagnosed with refractory epilepsy and hospitalized at Neuropediatric Service of Juan Manuel Márquezpediatric hospital from January 2002 to July, 2005. Variables such as sex, age at admission, onset of epilepsy, type of seizure, etiological diagnosis, previous drug failures, type of multitherapy and response one, three, six months and 1 year after treatment and adverse reactions to medication. It was concluded that epilepsy has an early onset, is the result of hypoxic damage and structural lesions of the brain in over 70% of cases, failed therapy with 2 to 4 drugs and that the most accepted multi-therapy was Valproate. Positive response to treatment occured in 67,9% of cases, seizures were half-reduced in 21,4% of the patients after one year of treatment. Epileptic spams associated to partial seizures showed later response than spams as the only form of seizure. Vigabatrin was well-tolerated and its adverse effects were transient and slight.

Keywords : refractory epilepsy; children; Vigabatrin; adverse effects.

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