Abstract

NAVEA LEYVA, Leonor M. et al. Anticuerpos neutralizantes frente a 5 cepas de VIH-1 en macacos inmunizados con el polipéptido multiepitópico TAB9. Rev Cubana Med Trop [online]. 2000, vol.52, n.2, pp. 115-118. ISSN 1561-3054.

Presence of neutralizing antibodies(Nab) to 5 laboratory strains of human immunodeficiency virus type-1 (HIV-1) was studied and compared in the sera of eight macaca (Macaca fascicularis) after the third and fourth immunizations with multi-epitope polypeptide TAB9, emulsified with adjuvant Montanide ISA 720. Four animals were innoculated 1mg and the others 200 µg, 2 animals were used as controls and injected only with adjuvant. Although the presence of neutralizing antibodies to homologous strains of HIV-group group B was confirmed in most animals after immunization through antigen p24 capture ELISA (DAVIH-Agp24, Cuba), no statistically significant differences were found neither in titers caused by antigen concentrations nor in the responses after the third and fourth immunizing dosis. Controls did not develop neutralizing antibodies.

Keywords : HIV-1 [immunology]; HIV-1 blood; HIV ANTIBODIES [immunology]; PEPTIDES; EPITOPES; MACACA; IMMUNIZATION; PASSIVE.

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