Abstract

HERNANDEZ RAMIREZ, Porfirio. Chronic lymphocytic leukaemia: Clinical and biological aspects. Rev Cubana Hematol Inmunol Hemoter [online]. 1999, vol.15, n.1, pp. 7-20. ISSN 1561-2996.

Chronic lymphocytic leukaemia (CLL) is the commonest type of leukaemia among Caucasian individuals. Its incidence varies a lot according to the geographical area. The most frequent variety is that of B lymphocytes described in this paper. Its etiology is unknow. Generally, the CLL may have a wide range of clinical manifestations and different complications. In approximately 10 to 30 % of the cases it is observed a change to a more aggressive lymphoproliferative process. The CLL is a heterogenous disease in this cytomorphological aspect and may present variations in its immunophenotypical, cytogenetic and molecular characteristics. The modern molecular techniques have demostrated a higher incidence of cytogenetic disorders than the traditional methods. The most frequent disorders were trisomy 12 and deletions of 11q and of 13q12-14. The molecular studies have not been able to identify an oncogen associated with the development of CLL. However, an active research in being carried out in this sense

Keywords : LEUKEMIA B-CELL, CHRONIC.

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