Abstract

VILLAESCUSA BLANCO, Rinaldo et al. Presence of circulating immune complexes and alterations of the complement system in patients with promyelocytic leukaemia and disseminates intravascular coagulation. Rev Cubana Hematol Inmunol Hemoter [online]. 1999, vol.15, n.1, pp. 30-34. ISSN 1561-2996.

The determination of the circulating immunecomplexes (CIC) as well as the measurement of the complement system were carried out by the classical pathway, alternate pathway, factor B activity and the quantitation of the third (C3) and fourth (C4) components of the complement in 30 patients with promyelocytic leukaemia (PML) on diagnosis, 22 of whom presented disseminated intravascular coagulation (DIC). It was proved the existance of elevated levels of CIC in patients with DIC and a marked reduction of the ativity of the classical pathway and of the C3 and C4 components in patients with DIC, on comparing them with the group of patients that did not have hemostasis disorder and with the normal controls, which suggest the possible participation of these parameters in the phenomenon of DIC in these patients

Keywords : DISSEMINATED INTRAVASCULAR COAGULATION [immunology]; LEUKEMIA, PROMYELOCITIC ACUTE [immunology]; ANTIGEN-ANTIBODY COMPLEX [analysis]; COMPLEMENT [analysis].

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