Abstract

MARSAN SUAREZ, Vianed et al. Cellular immunophenotyping in the diagnosis of acute hybrid leukemias. Rev Cubana Hematol Inmunol Hemoter [online]. 1999, vol.15, n.3, pp. 190-196. ISSN 1561-2996.

118 acute leukemias were studied during 4 years. The cellular phenotyping was carried out through the immunocytochemical ultramicromethod by using a panel of monoclonal antibodies with which the expression of lymphoid and myeloid antigens was evaluated. The expression of myeloid antigens in patients with acute lymphoid leukemia was found in 28.4 %, whereas the expression of lymphoid antigens in patients suffering from acute myeloid leukemia was observed in 56.7 %. The acute hybrid leukemias accounted for 16.1 % of the total of patients studied: 73.7 % at the onset of the disease and the other 26.3 % in the study following the induction treatment of the referred patients, which suggests in the latter the possibility of changing lineage by selecting variantes resistant to drugs from the original clon, or the appearance of secondary neoplasias due to the use of genotoxic drugs

Keywords : IMMUNOPHENOTYPING; IMMUNOHISTOCHEMISTRY [methods]; LEUKEMIA, MYELOCYTIC, ACUTE [diagnosis]; LEUKEMIA, LYMPHOCYTIC [diagnosis].

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )