Abstract

ALPIZAR OLIVARES, Yulién et al. Study of drug reactions due to delayed hypersensitivity by lymphoblastic proliferation. Rev Cubana Hematol Inmunol Hemoter [online]. 1999, vol.15, n.3, pp. 197-203. ISSN 1561-2996.

6 patients with the possible diagnosis of drugs reactions due to delayed hypersensitivity (DH) were studied by using the test of lymphoblastic transformation with criterion of incorporation of tritiated thymidine. It was proved that in 2 patients there DH reactions to carbamazepine, in one to aspirin, in one to chloroquine and sulfaprim, and the other patient to aspirin in tablets and to the raw material. It was proved that the introduction of this method for evaluating the reaction of type IV DH in the study of adverse reactions to drugs is very useful in our environment. The therapeutic conduct was modified in each patient according to the results obtained, which favored the prognosis, hospital stay and healing

Keywords : HIPERSENSITIVITY, DELAYED [blood]; LYMPHOCYTE TRANSFORMATION; CHLOROQUINE [adverse effects]; CARBAMAZEPINE [adverse effects]; ASPIRIN [adverse effects]; TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION [adverse effects]; THYMIDINE.

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