Abstract

MILANES ROLDAN, María Teresa et al. Clinical and epidemiological aspects of acute myeloid leukemia in the elderly. Rev Cubana Hematol Inmunol Hemoter [online]. 2002, vol.18, n.1, pp. 0-0. ISSN 1561-2996.

An updating study of the clinical-epidemiological aspects of acute myeloid anemia in the elderly was conducted. It set forth the clinical, morphological, cytogenetic and biological characteristics of the disease. It was underlined that the elderly have specific biological differences in relation to the young patient, which give them a worse prognosis since such differences are related to a poorer response to chemotherapy. Similarly, the study listed the main prognostic factors affecting the success of AML treatment in the elderly, such as age, functional state at the onset of disease, chromosomal abnormalities and P-glycoprotein expression. Both incidence and mortality are higher in older people than in young people and the general results of the AML treatment in these aged patients are increasingly discouraging because it is observed that complete remission and disease-free survival rates in the elderly are much lower than in young patients. Therefore, a therapeutical differentiation aimed at using the most suitable scheme to obtain better results is suggested in this type of patients

Keywords : LEUKEMIA, MYELOID [diagnosis]; LEUKEMIA, MYELOID [epidemiology]; LEUKEMIA, MYELOID [genetics]; AGED.

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