Abstract

MARSAN SUAREZ, Vianed et al. Immunophenotyping and global survival of pediatric patients with acute leukemia. Rev Cubana Hematol Inmunol Hemoter [online]. 2002, vol.18, n.1, pp. 0-0. ISSN 1561-2996.

Cell immunophenotyping (CIP) identifies the specific line of origin of leukemic cells and their maturing level. The frequency of the various immunological subtypes of acute leukemias (AL) and their possible relationship with global survival rate of patients were determined. One hundred and seventeen children with AL were studied from 1983 to 1999. The CIP was conducted through the immunocytochemical ultramicromethod and the alkaline phosphatase - anti-alkaline phosphatase method. Seventy seven (65,8%) of all AL were acute lymphoid leukemias (ALL), 26(22,2%) acute myeloid (AML), 9 (8%) undifferentiated AL, and 5 (4%) were hybrid AL. Fifty-nine (76,6%) ALL belonged to phenotype B and 18 (23,4%) to phenotype T. A higher survival rate was observed in phenotype B ALL patients than in phenotype T ALL and myeloid anemia patients, with a very significant difference (p< 0,001). Survival was also analyzed among the various types of phenotype B acute leukemias; a lower survival rate was observed in patients with more immature phenotypes

Keywords : IMMUNOPHENOTYPING; LEUKEMIA, MYELOID [diagnosis]; LEUKEMIA, MYELOID [classification]; LEUKEMIA MYELOID [immunology]; LEUKEMIA, LYMPHOCYTIC [diagnosis]; LEUKEMIA, LYMPHOCYTIC [classification]; LEUKEMIA, LYMPHOCYTIC [immunology]; MONOCLONAL ANTIBODIES [diagnostic use]; SURVIVAL RATE; CHILD.

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