Abstract

MOLINA CASTRO, Randelys et al. Evaluation of the opsonophagocytic function of neutrophils in HIV-infected patients. Rev Cubana Hematol Inmunol Hemoter [online]. 2002, vol.18, n.1, pp. 0-0. ISSN 1561-2996.

The dysfunction of neutrophils could contribute to susceptibility to infections observed in HIV-infected patients. A cross-sectional study was conducted to evaluate the opsonophagocytosis of neutrophils in these patients. One hundred and four individuals participated in it: 25 blood donors (the control group) and 79 HIV-positive patients who were distributed into 3 groups according to the global count of CD4 lymphocytes (GLCCD4): Group 1 composed of 24 individuals with GLCCD4³ 500 cell/mm3, Group 2 with 26 patients with GLCCD4 of 200-499 cell/mm3 and Group 3 composed by 29 patients with GLCCD4 < 200 cell/mm3 . Absolute values of leukocytes and granulocytes and relative values of lymphocytes were determined, CD4+ lymphocyte T subset was quantified and the opsonophagocytic index was estimated. A significant reduction (p< 0,05) in absolute count of leukocytes and granulocytes and in the opsonophagocytic function was found in HIV-infected patients compared with the control group. There was a non-linear direct relation of the absolute count of CD4+ T lymphocytes with global count of leukocytes and granulocytes and the opsonophagocytic function

Keywords : VIH [immunology]; NEUTROPHILS [immunology]; ACQUIRED IMMUNODEFICIENCY SYNDROME [immunology]; CD4 LYMPHOCYTE COUNT [analysis]; PHAGOCYTOSIS; GRANULOCYTES [immunology].

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