Abstract

VILLAESCUSA BLANCO, Rinaldo et al. Possible role of the complement system in the development of autoimmune manifestations in chronic lymphocytic leukemias. Rev Cubana Hematol Inmunol Hemoter [online]. 2002, vol.18, n.1, pp. 0-0. ISSN 1561-2996.

The measurement of the activity of the classical pathway, the alternative pathway, factor B, factor D, as well as the quantification of Clq, C3 and C4 of the complement system were made in 27 patients with type B chronic lymphocytic leukemia (CLL-B) CD5+, classified into 2 groups: 12 patients at little advanced stage of the disease (stages 0, I, II) and 15 patients at advanced stage (stages III, IV). It was proved that the activity of the classical pathway and the concentration of Clq and C4 lowered in 10 patients at advanced stage, 7 of them also had autoimmune hemolytic anemia. Neither complement deficiencies nor autoimmune manifestations were shown in the group of patients at little advanced stage of the disease. Collected data indicates the possible involvement of the complement system in keeping the immune tolerance, the rupture of which may cause the synthesis of anti-erythrocyte antibodies and thus, the hemolytic anemia that occurs in certain patients at advanced stage of the disease

Keywords : LEUKEMIA, B-CELL, CHRONIC [immunology]; AUTOIMMUNE DISEASES; COMPLEMENT [immunology]; ANEMIA, HEMOLYTIC, AUTOIMMUNE [immunology].

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