Abstract

DIAZ CONCEPCION, Alina. Acquired von Willebrand’s disease. General aspects. Rev Cubana Hematol Inmunol Hemoter [online]. 2004, vol.20, n.1, pp. 0-0. ISSN 1561-2996.

The acquired Willebrand’s disease is a rare hemorrhagical disease. Approximately in half of the cases, it is associated with lymphoproliferative diseases and it has been also related to myeloproliferative disorders, neoplasias, immunological and cardiovascular diseases, and other clinical conditions. It must be suspected in all patients presenting a hemorrhagic diathesis of late appearance with no personal or family history of coagulopathy. The clinical symptoms are similar to those of congenital Willebrand’s disease. This disease seems to have a multifactorial ethiology. In most of the affected patients. The von Willebrand factor (vWf) is normally synthesized; however, it is rapidly removed from plasma through different mechanisms, whose final common result is the reduction of the circulating levels of this factor. The clinical laboratory tests include the exploration of primary hemostasia and the specific tests for determining the antigenic and functional activity of vWF. The treatment has 2 main objectives: to correct the acute bleeding episodes and to treat the underlying disease and associated conditions

Keywords : von Willebrand; acquired.