Abstract

HERNANDEZ RAMIREZ, Porfirio. ZAP-70: a new prognostic factor in chronic lymphocytic leukemia. Rev Cubana Hematol Inmunol Hemoter [online]. 2004, vol.20, n.3, pp. 0-0. ISSN 1561-2996.

In B-cell chronic lymphocytic leukemia (B-CLL), different prognostic factors have been presented to predict the course of the disease. Recently, there has been added a new prognostic factor determined by the expression of 70kDa protein that is associated with T-cell receptor zeta chain and known as ZAP-70. This protein does not express in normal B lymphocytes but it does in those of a B-CLL subgroup that do not have IgVH heavy chain variable-region gene mutations. Recent studies indicate that the expression of this protein in leukemic lymphocytes could contribute to a more aggressive course of B-cell chronic lymphocytic leukemia without IgVH gene mutations. Likewise, it has been pointed out that the determination of ZAP-70 can provide a simpler prognostic factor than the present characterization of the IgVH gene mutational state

Keywords : B-CLL; prognostic factors; CD38; IgVH genes; ZAP-70.