Abstract

BRAGOS, Irma Margarita; NOGUERA, Nélida Inés; RAVIOLA, Mariana Paula  and  MILANI, Ángela Cristina. Molecular genetics of the heterozygous beta-thalassemia: Interrelation with hematological parameters. Rev Cubana Hematol Inmunol Hemoter [online]. 2005, vol.21, n.1, pp. 0-0. ISSN 1561-2996.

No data have been published in Argentina about the interrelation existing between the phenotype of the mutation responsible for b-thalassemia (b+ or bO) and the hematological parameters. In the present paper, 6 of the most frequent mutations occurred in the Mediterranean zone in 99 non-related carriers of beta-thalassemia from Rosario and the influence zone, were studied. The hematimetric parameters and the erythrocytic morphology of peripheral blood of the carriers of beta-thalassemia did not allow to suspect of a determined mutation. Slightly significant differences (p < 0.10) were found in the average values of HCM for the different mutations considered. For the genotype b + I-6, it was marginally higher than for the genotype b + II-745. There were no significant differences among the other 4 genotypes

Keywords : Beta-thalassemic trait; hematological parameters; mutations.

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