Abstract

FUNDORA SARRAFF, Teresa A et al. Effect of hemin-arginine and QF12 on the incorporation of 59 Fe in mice erythrocytes. Rev Cubana Hematol Inmunol Hemoter [online]. 2006, vol.22, n.1, pp. 0-0. ISSN 1561-2996.

The effect of 2 hemin compounds (hemin-arginine and QF12 ) obtained at the Center of Pharmaceutical Chemistry on the percentage of incorporation of 59 Fe in the circulating erythrocytes of normal mice was studied. A statistically significant difference was observed between the 2 groups on the second day (p = 0.022). In the a posteriori tests it was found that the average percentage of incorporation of 59 Fe of the group that received QF12 at 6 mg/kg was markedly higher than the one obtained with placebo (p = 0.021), and remarkably higher than the found with hemin-arginine at 3 mg/kg (p = 0.021), and with hemin-arginine at 6 mg/kg (p = 0.016) on the second day after the injection of 59 Fe. The obtention of QF12, the first Cuban heminic compound, and the success attained in its first preclinical test, allowed to request its patent

Keywords : Hemin; hemin-arginine; QF12; incorporation of 59 Fe in the red corpuscles; panhemopoietine.