Abstract

CORTINA ROSALES, Lázaro  and  LOPEZ DE ROUX, María del Rosario. Immediate immune hemolytic transfusional reaction. Rev Cubana Hematol Inmunol Hemoter [online]. 2006, vol.22, n.2, pp. 0-0. ISSN 1561-2996.

The immediate immunological hemolytic reaction is the main cause of death associated with transfusion. The antigen-antibody reaction with the subsequent .hemolysis of erythrocytes triggers a systemic inflammatory response syndrome resulting from the release of cytokines (tumoral a necrosis factor, interleukin 1, interleukin 8, interleukin 6) and from the activation of enzymatic amplification systems (coagulation, fibrinolysis, calicrein-bradykinin). The disseminated intravascular coagulation and the acute renal failure are physiopathological events that stand out in the clinical picture. Pretransfusional protocols that provide multiple safety steps, and whose fulfiment discards the occurrence of fatal reactions, have been developed. However, the idenfication erros, the lack of knowledge and negligence are still present and are considered as its fundamental causes

Keywords : Hemolysis; antigen-antibody reaction; cytokines; pretransfusional protocol.