Abstract

VILLAESCUSA BLANCO, Rinaldo et al. Natural anti-band 3 antibodies: Do they take part in the phenomenon of vasoocclusion drepanocytosis. Rev Cubana Hematol Inmunol Hemoter [online]. 2007, vol.23, n.1, pp. 0-0. ISSN 1561-2996.

The presence of natural anti-band 3 antibodies was determined by an immunoenzymatic assay in microplaques coupled with band 3 protein in 14 patients with drepanocytosis, 4 with painful vasoocclusive crisis and 10 in the basal state. It was proved a significant reduction (p = 0,000005) of the levels of natural anti-band 3 antibodies in all the patients on comparing them with the normal controls, which may be related to an elevated consumption of these in the clearance process of oxidized or senescent erythrocytes with hemoglobin SS. There was no statistical difference between the group of patients in the basal state and those with painful vasoocclusive crisis, which suggests that the natural anti-band 3 antibodies do not take part in the modulation of the occlusive phenomenon that is produced in this disease. The longitudinal study of a greater number of patients that allows to go deep into this apect is recommended

Keywords : natural anti-band 3 antibodies; painful vasoocclusive crisis; drepanocytosis; band 3 protein.