Abstract

LAVAUT-SANCHEZ, Kalia  and  HERNANDEZ-RAMIREZ, Porfirio. Contribution of current genetics to development of cellular reprogramming. Rev Cubana Hematol Inmunol Hemoter [online]. 2010, vol.26, n.4, pp. 293-305. ISSN 1561-2996.

The advance of the genetics and specially of the molecular biology, gave rise to a new era: the genomic and to new concepts like transcriptome, proteome, metabolome, epigenome allowing us to study the structure, organization and function of all the genes and its products, as well as the mechanisms involved in regulation of its expression and the way in which some genes interacting each other. The use of new technologies in research of stem cells favored the development of induced pluripotent stem cells using the many methods for its detection. It was demonstrated that the addition of a reduced number of genes allows the reprogramming of somatic cells and the formation of pluripotent stem cells with embryonic features, without the use of human embryos, which has its ethical connotations and potential therapeutic applications in regenerative medicine.

Keywords : Genomics; stem cells; cellular reprogramming; induced stem cells.

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