Abstract

SCHERLE-MATAMOROS, Claudio Enrique et al. Risks of ischemic stroke in children suffering Sβ-thalassemia. Transcranial Doppler study. Rev Cubana Hematol Inmunol Hemoter [online]. 2012, vol.28, n.2, pp. 169-176. ISSN 0864-0289.

In children with sickle cell anemia, the risk of ischemic stroke varies according to genotype of hemoglobinopathy. In these cases, determining the velocity of blood flow by transcranial Doppler (TCD) can predict the occurrence of cerebral ischemia. In order to describe the characteristics of DTC in Sβ thalassemia, we studied 32 patients younger than 18 treated at the Institute of Hematology and Immunology, who were referred for ultrasound assessment. The age rate of children was 10.5 years old. We studied the same number of patients with each genotype Sβ, in only one patient the time window was not useful. 97 % of patients the mean flow velocity in the middle cerebral arteries was less than 170 cm/s and only one child was in the range of conditional group. Interhemispheric asymmetries were registered in the average flow rate of the anterior cerebral arteries in 29 % cases, 19.6 % registered it in the middle cerebral arteries, and 6.4 % in the extracranial internal carotid. The highest levels of average flow rate were registered in patients with thalassemia Sβ⁰ and middle cerebral arteries. There was an inverse correlation between age and hemoglobin levels with the flow rate of three studied vessels. The risk of ischemic stroke in the Sβ thalassemia is low, with no difference between the two assessed genotypes.

Keywords : anemia; Sβ talassemia; transcranial Doppler; ictus; cerebro-vascular desease.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )