Abstract

ROMERO GONZALEZ, Adrián et al. Absolute lymphocyte count as a predictor in hematopoietic transplantation. Rev Cubana Hematol Inmunol Hemoter [online]. 2013, vol.29, n.3, pp. 246-255. ISSN 0864-0289.

Early recovery of lymphocytes is a prognostic factor that is related to a higher event-free survival and overall survival after haematopoietic stem cell transplantation. A literature review was conducted in order to determine the prognostic value of absolute lymphocyte count in patients with hematological malignancies after transplantation. Autologous transplant patients reach an absolute lymphocyte count on day + 15 (RAL15) e» 500 x mm³, earlier than allogeneic. The RAL15 when peripheral blood is used is greater than when using the bone marrow. Prognostic factors associated with worse overall survival were sepsis, RAL 15 <500x mm³ and relapse. Several studies show a better overall survival and event-free survival at five years in patients with e» 500 x RAL15 mm³. The RAL15 e» 500 x mm³ is a simple and useful tool to predict a better outcome in patients undergoing hematopoietic transplantation.

Keywords : absolute lymphocyte count; hematopoietic transplantation; prognostic factor.

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