Abstract

URRUTIA FEBLES, Yaima  and  CASTILLO GONZALEZ, Dunia C. Fibrinolysis and SARS-CoV-2. Rev Cubana Hematol Inmunol Hemoter [online]. 2023, vol.39  Epub June 26, 2023. ISSN 1561-2996.

The regulation of the fibrinolysis system is mediated by specific molecular interactions between its main components and by the synthesis and subsequent release from endothelial cells of plasminogen activators and inhibitors. Therefore, an increase in the activity of the fibrinolysis system favors the appearance of bleeding disorders, while a defect in fibrinolytic activity may predispose to thrombosis.

Alterations in fibrinolysis have also been reported in patients with SARS-CoV-2. Attenuation of the plasminogen activation system leads to abnormal fibrin turnover in the alveolar space with the development of thrombosis. Plasma PAI-1 levels have been reported to be a risk factor for poor prognosis and mortality in patients with Covid-19.

Keywords : fibrinolysis; thrombosis; SARS-CoV-2; COVID-19; PAI-1.

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