Abstract

DIEZ GOMEZ, Norma; MACIAS BETANCOURT, René  and  PEDROSO IBANEZ, Ivonne. El factor de activación plaquetaria y su relación con el daño oxidativo. Rev Cubana Invest Bioméd [online]. 2001, vol.20, n.1, pp. 64-69. ISSN 1561-3011.

The platelet activating factor is an endogenous synthesis phospholipid directly linked to a series of processes such as ischemia, necrosis, thrombosis and others. The main target of its deleterous effects is found in endotelial cells, leukocytes and platelets whereas it causes serious mechanical, reologic and biochemical disturbances in the circulation unit. A literature review was made on plaletet-activating factor, its endogenous synthesis, biological functions with special emphasis on the relation of this factor with oxidative damage and the main known antagonists. The effect of ginkgolids contained in EGB 761 (Ginkgo biloba extract) and their application for treating several pathological processes related to brain and peripheral circulation were emphazided

Keywords : PLATELET ACTIVATING FACTOR [biosynthesis]; PLATELET ACTIVATING FACTOR [antagonists & inhibitors]; GINKGO BILOBA [therapeutic use]; FREE RADICALS; PLANTS, MEDICAL [therapeutic use]; HERBAL, MEDICINE; CEREBRO VASCULAR CIRCULATION [drug therapy].

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