Abstract

LOY, Sulay; SIMON, Rafael  and  DELGADO, René. VIMANG, un potencial protector de la peroxidación lipídica en lipoproteínas de baja densidad. Rev Cubana Invest Bioméd [online]. 2002, vol.21, n.3, pp. 167-170. ISSN 1561-3011.

An investigation was carried out to know if Vimang, an extract from the cortex of the stem of Mangifera indica L, protects low density lipoproteins from the in vitro oxidation mediated by ions of Cu++ . To this end, low density lipoproteins obtained by ultracentrifugation from blood samples of sound volunteers, were oxidized by incubation with CuS04 at 37 °C during 3 hours in the presence of different doses of Vimang (0.0001-0.1 % w/v), as a model to investigate the antioxidant properties of this product. The lipid peroxidation was measured as reactive substances to tiobarbituric acid, The assayed doses of Vimang showed a potent antioxidant action. Only the lowest dose allowed a discrete formation of lipid peroxides in low density lipoproteins after 3 hours of incubation on comparing them with the low density lipoproteins controls. The final result is an evidence of the possible use of Vimang as an antioxidant in the prevention or delay of atherosclerosis.

Keywords : LIPOPROTEINS, LDL; ATHEROSCLEROSIS [etiology]; ATHEROSCLEROSIS [prevention & control]; PLANTS, MEDICINAL; PLANT EXTRACTS [therapeutic use]; MANGIFERA INDICA; ANTIOXIDANT [therapeutic use].

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