Abstract

DIAZ ARCE, Dariel. Hyperglycemia and oxidative stress in the diabetic patient. Rev Cubana Invest Bioméd [online]. 2006, vol.25, n.3, pp. 0-0. ISSN 1561-3011.

Some evidences that relate the oxygen reactive species to the main mechanisms and that explain the complications observed in patients with diabetes mellitus were reviewed. The generation of advanced glycation products, the activation of the pathway of the polyols and of hexosamines, as well as the activation of the proteins kinase C are closely associated with the generation of oxygen reactive species that lead to a chronic oxidative stress in these patients. Some references suggesting that a possible antioxidant treatment may improve their clinical picture were reviewed.

Keywords : Oxygen reactive species; hyperglycemia; oxidative stress; diabetes mellitus.