Abstract

HERRERA BATISTA, Aleida; PULDON SEGUI, Giselle  and  RUIZ CANDINA, Héctor. Alterations in the morphometric features of kidney of male albino rats provoked by chronic ingestion of ethanol from the adolescence. Rev Cubana Invest Bioméd [online]. 2010, vol.29, n.2, pp. 194-202. ISSN 1561-3011.

Present paper allowed us to determine the variations exerted by the chronic ingestion of ethanol from the adolescence on the kidney morphometric features in 42 male albino rats of 30 days born divided into two groups of 21 animal each and with the treatment times of three and five months and with these 42 animals into two subgroups: one of experimental type and other as control. The experimental rats received ethanol at 5 g/kg doses according to the body weight using an intraesophageal cannula. The control ones received water instead of ethanol in similar conditions. We used histological sections stained with PAS technique to study the outlined portions of the proximal and distal tubules. The tubular transversal section area was estimated measuring the nuclear volumes of cells in both tubules. It was demonstrated that the experimental rats showed higher values of the transversal section of renal tubules higher than the control ones, where these values were superior in proximal tubules in the five months old rats and the distal ones in the three months old. We conclude that in study sample the chronic alcoholism started during adolescence provoked morphometric variations in proximal and distal tubules of kidney.

Keywords : Adolescence; chronic alcoholism; nuclear volume; kidney; rat; renal tubules; morphometry.

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