Abstract

HERNANDEZ REQUEJO, Daymé  and  PEREZ AVILA, Jorge. Causes of change in treatment in a group of HIV/AIDS Cuban patients. Rev Cubana Invest Bioméd [online]. 2010, vol.29, n.2, pp. 223-230. ISSN 1561-3011.

The HIV virus infection is one of the major current problems of health estimating that more than 40 millions of persons are infected at world level. A cross-sectional and descriptive study was conducted in 40 HIV/AIDS patients from the Tropical Medicine Institute service to characterize the causes of the change in antiretroviruses treatment and the types of adverse reactions related to this treatment in a group of HIV/AIDS patients. Patients received different antiretroviruses schemes with predominance of 3TC, d4T and Indinarir (57,5%), followed by 3TC, AZT and Indinavir (22,5%). The more frequent causes of change of this treatment were the adverse reactions and a poor adherence to it. Among the persons with therapy HIV there is a more and more frequent trend to give up or to change of therapy. The causes of these changes and the leaving the therapy are related to side effects, treatment fatigue, and the HIV infection phase in patient and relative factors related to the lifestyle. The more frequent causes of the change of treatment were the adverse reactions followed by a poor adherence to antiretroviruses treatment. The more frequent adverse reactions were vomiting and digestive disorders, respectively.

Keywords : HIV/AIDS; antiretroviruses treatment HAART therapy; T CD+4 lymphocytes; viral burden.

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