Abstract

PULDON SEGUI, Giselle; HERRERA BATISTA, Aleida  and  RUIZ CANDINA, Héctor. Effects of chronic ingestion of ethanol on the histological features of the adolescent male rats' kidney. Rev Cubana Invest Bioméd [online]. 2010, vol.29, n.4, pp. 445-453. ISSN 1561-3011.

We intended to know the effects of chronic alcoholism during the adolescence on the histological features of rats' kidney. In study were included 42 male rats of 30 days of postnatal life divided into two groups of 21 animals each treated over 3 and 5 months and with each group, 2 subgroups: experimental (E) and control. The E group rats received ethanol in a dose of 5/kg of body weight and C group received water, both by intraesophageal cannula. At the end of experiment both kidneys were removed with histological sections stained with hematoxylin and eosin, as well as corpuscules with a lack of continuity of parietal folium. Many renal tubules showed a lumen increase and signs of tubulorrhexis. The 5 months of life had collapsing focal glomerulosclerosis with a decrease of glomerular size and large amplitude of capsular space. Some glomeruli had signs of leukocyte infiltration and hyaline material. There were renal tubules very dilated, some showed a wall with simple epithelium, acidophilic material by light and signs of tubulorrhexis. We conclude that ingestion of high doses of ethanol provoked severe histological alterations at level of glomeruli and renal tubules.

Keywords : Alcoholism; adolescence; kidney; rats; renal tubules; glomeruli.

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