Abstract

BARBER FOX, María Ofelia; GALVIZU DIAZ, Katiana; PEREZ RAMOS, Aydelín  and  FOX PASCUAL, María Ofelia. Pathophysiological mechanisms of the lack of glomerulus-tubule balance in arterial high blood pressure. Rev Cubana Invest Bioméd [online]. 2010, vol.29, n.4, pp. 463-478. ISSN 1561-3011.

The current trends and hypotheses to know the etiopathogenesis mechanisms of the essential arterial high blood pressure involved the renal system as a prevailing mechanism in the long-term regulation of arterial pressure and the existence in it of some phenomenon that could lead to a glomerulus-tubule lack of balance with tubular preponderance. Although the analysis of this latter fact, has not been approached as such in pathogenesis of hypertensive syndrome. With the aim of to interpret the role of glomerulus-tubule lack of balance with tubular preponderance in pathophysiology of arterial high blood pressure as a phenomenon in which converging multiple renal pathophysiological mechanisms already described, these latter were reviewed in a integrated way and its causal relation with the above mentioned lack of balance with tubular preponderance. This preponderance, a common point of discussed mechanisms, favors the decrease of a fractional releasing of Na+, the hydrosaline retention and the raise of arterial pressure.

Keywords : Tubular-glomerular lack of balance; arterial high blood pressure and kidney; tubular function and high blood pressure.

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