Abstract

FERNANDEZ ABREU, María Elena et al. Cuban low-thickness sintered hydroxyapatite disks as a drug release system. Rev Cubana Invest Bioméd [online]. 2013, vol.32, n.3, pp. 244-253. ISSN 0864-0300.

Objective: the main purpose of this study is to examine the potential use of Cuban hydroxyapatite (HA) disks as a controlled drug release system. These disks are manufactured by pressing, and sintered in electric furnaces without using pore-forming agents, with apparent porosities of 12, 20 and 40%, and doped by overpressure with a 5% sodium alginate aqueous solution and 55 ppm ceftazidime. Methods: a study was conducted of the relationship between penetration of the polymer and apparent porosity with the release of the drug. Results: it was shown that when infiltrated with the polymer encapsulating the drug, these disks may be used as a controlled release system. It was also found that apparent porosity and pore size influence polymer penetration and the mass of drug released. Conclusions: the release curves obtained show that the disks may be a potential drug-supporting material, capable of controlling the release of the remnant drug occluded by an overpressure doping method. The profile reveals that controlled release of the drug is completed in seven days.

Keywords : hydroxyapatite disks; biomaterials; drugs; controlled release system; bioactivity.

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