Abstract

PADILLA-DOCAL, Barbara et al. Reibergram to evaluate the Mannan binding Lectin intrathecal synthesis. Rev Cubana Invest Bioméd [online]. 2014, vol.33, n.2, pp. 168-176. ISSN 0864-0300.

Background: The dynamics of brain derived proteins in cerebrospinal fluid is different from the dynamics of blood-derived proteins. Aim: To describe the empirical data for mannan binding lectin and gives a theoretical interpretation of the dynamics of this protein in cerebrospinal fluid through a new reibergram. Methods: Serum and cerebrospinal fluid mannan binding lectin were measured in 40 normal adults by immunofluorometric assays. The diagnostic criteria were based in; normal control samples defined clinically and diseases with blood-cerebrospinal fluid barrier dysfunction. Results: Correlation coefficient between cerebrospinal fluid MBL and serum MBL was very low. Mannan binding lectin reibergram was designed according with previous procedures. Conclusion: Under all conditions of the blood-cerebrospinal fluid barrier, the reibergram can identify the occurrence of intrathecal mannan binding lectin synthesis.

Keywords : Blood-cerebrospinal fluid barrier; cerebrospinal fluid; complement system; mannan binding lectin; reibergram.

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