Abstract

RIVERO SANTAMARIA, Alejandro et al. Characterization of - macroaggregates formulation. Nucleus [online]. 2009, n.45, pp. 11-18. ISSN 0864-084X.

ABSTRACT The aim of this paper was to study the formation and radiolabelling of 99m Tcalbumin macroaggregates. Comparatives studies of three formulations to establish the role of denaturalization and in the formulation of -Sn-MAA were carried out. A qualitative structural analysis of human serum albumin was performed in order to give a description of the studied system using a graph model. The results showed important differences in the radiochemical behavior of the three formulations. -Sn-MAA (A) formulation had the best behavior, with radiochemical purity close to 95% and dissociation below 20% after 24 h of being radiolabeled. The graph model explained with simple representations the process involved in the studied system;thus allowing a better knowledge of it.

Keywords : albumins; technetium 99; labelling; tin; comparative evaluations; centrifugation; chromatography; protein denaturation.

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