Abstract

BORRERO SANCHEZ, Judith et al. Molecular mechanisms involved in atherothrombotic cardiovascular disease. Rev Cubana Med Gen Integr [online]. 2012, vol.28, n.3, pp. 290-298. ISSN 0864-2125.

Acute coronary syndrome is a health problem and is the leading cause of death in Europe, North America, and Cuba. This disease, which includes heart attack, angina and sudden death, causes more deaths each year than all other diseases combined. The most important causal factor of myocardial infarction lies in the formation and chronic evolution of atheroma, or events that are favored by oxidative stress, proinflammatory cytokines, thrombin and no control of risk factors. This review was conducted in order to explain the molecular mechanisms and the influence of the risk factors involved in the pathophysiology of these diseases. It was concluded that reactive oxygen species and oxidative stress play an important role in the pathophysiology of such cardiovascular disorders, of relevance for its diagnosis and therapy.

Keywords : reactive oxygen species; oxidative stress; atherothrombotic cardiovascular disease.

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