Abstract

SANTOS LAGRESA, María Nila; MARTINEZ SUAREZ, Nereyda; VILCHES LESCAILLE, Deysi  and  SANTOS LAGRESA, Caridad Marisela. Tears inducers: androgens and human gammaglobulinas. Rev Cubana Oftalmol [online]. 2000, vol.13, n.1, pp. 0-0. ISSN 1561-3070.

Therapeutical responses are compared in patients diagnosed of Sjögren syndrome, presenting with keratoconjunctivitis sicca resistant to traditional treatments of artificial tears, lenses and others in two groups of patients (18 and 32 cases) treated with human gammaglobulin: intacglobin (100 mg/body weight every 15 days in a intercapsular subcutaneos way for 3 months), and depot androgens (100 mg every 15 days in an intramuscular way for three months). Level of IgG, IgA, IgM, and IgE immunoglobulins, count of blood cells-rheumatoid factor, C-reactive protein, and microbiological study. Both treatments show an significant statistically improve p < 0,001 in results obtained in Shirmer I test, and in negative corneal injuries, assessed using slit lamp after fluorescein staining. We propose advantageous use of gammaglobulins because of contraindications on utilization of androgens.

Keywords : SJOGREN´S SYNDROME; KERATOCONJUNCTIVITIS [therapy].

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