Abstract

RODRIGUEZ LOPEZ, Aquiles José; BALLESTER PEREZ, Arvelio; SALELLAS BRINGUEZ, Julieta  and  NICOLAU PESTANA, Elizabeth. Resistance level to quinine plus doxiciline in chloroquine-resistant malaria. AMC [online]. 2010, vol.14, n.1, pp. 0-0. ISSN 1025-0255.

Background: the high incidence of the resistance to antimalarial drugs has determined that treatment strategies currently are based in the association of at least two different agents. Objective: to determine the response to the combination of quinine plus doxicicline in patients carriers of chloroquine-resistant malaria in Republic of Gambia. Method: a quasi experimental study in one-hundred sixty five patients that presented non complicated forms of chloroquine-resistant malaria was performed, admitted in the Hospital Royal Victoria of Banjul, Gambia, from January 1st 2006 to June 30 2007. Results: most of the included patients had less than forty five years (75,15%). The resistance level in vivo to the analyzed therapy was about 4,85%. Most of the patients presented at least one adverse effect, the most frequent were: vertigo, tinnitus and hypoacusis. Conclusions: the resistance level to the studied combination was notably low, although with a high index of adverse effects.

Keywords : doxiciclina [uso terapéutico]; resistencia a múltiples medicamentos; malaria [therapy]; chloroquine [therapy use]; quinine [therapy use]; doxycycline [therapy use]; drug resistant; multiple.

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